PI3K Signaling Pathway in Normal B Cells and Indolent B Cell Malignancies

In chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas (NHL), B cell receptor signaling leads to activation of the PI3K pathway. Idelalisib, a PI3K δ inhibitor was approved in 2014 by the US Food and Drug Administration (FDA) in combination with rituximab for the treatment of patients with CLL for whom single agent rituximab would be considered appropriate and as a single agent for patients with relapsed small lymphocytic lymphoma (SLL) and re lapsed follicular lymphoma (FL). Following its approval, several trials investigating various PI3Kδ inhibitors as single agents or in combination with chemoimmunotherapy or other molecular targeted agents in CLL and indolent NHL (iNHL) have uncovered some severe autoimmune related toxicities.
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research