Unmasking of Myoclonus by Lacosamide in Generalized Epilepsy

We report a 67-year-old woman who experienced new-onset myoclonic seizures after initiation of lacosamide. We presume that she had an undiagnosed generalized epilepsy syndrome, likely juvenile myoclonic epilepsy. Myoclonic seizures were not reported before introducing lacosamide and completely resolved after lacosamide was discontinued. This suggests that lacosamide may have the potential to worsen myoclonus, similar to what has been reported with another sodium channel agent, lamotrigine, in some individuals with idiopathic generalized epilespy.

Source: Epilepsy and Behavior Case Reports - November 16, 2016 Category: Neurology Source Type: research