Human Endomyocardial Biopsy Specimen-Derived Stromal Cells Modulate Angiotensin II-Induced Cardiac Remodeling

This study demonstrates that cells derived from human endomyocardial biopsies, cardiac-derived adherent proliferating cells (CardAPs), have the potential to reduce angiotensin II-induced cardiac remodeling and improve left ventricular function in angiotensin II mice. The mechanism involves antifibrotic and antihypertrophic effects via paracrine actions and immunomodulatory properties. These findings support the potential of CardAPs for the treatment of heart failure.

Source: Stem Cells Translational Medicine - November 16, 2016 Category: Stem Cells Authors: Miteva, K., Van Linthout, S., Pappritz, K., Muller, I., Spillmann, F., Haag, M., Stachelscheid, H., Ringe, J., Sittinger, M., Tschope, C. Tags: Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research