Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model

This study evaluated the role of exosomes isolated from mesenchymal stem cell (MSC)-conditioned medium (MSC-CM) in the fracture-healing process of CD9–/– mice, a strain that is known to produce reduced levels of exosomes. Retardation of fracture healing in CD9–/– mice was rescued by the injection of MSC exosomes, but this was not the case after the injection of exosome-free CM. This study finds that MSC exosomes are a novel factor of MSC paracrine signaling, with an important role in the tissue repair process.

Source: Stem Cells Translational Medicine - November 16, 2016 Category: Stem Cells Authors: Furuta, T., Miyaki, S., Ishitobi, H., Ogura, T., Kato, Y., Kamei, N., Miyado, K., Higashi, Y., Ochi, M. Tags: Mesenchymal Stem Cells, Tissue-Specific Progenitor and Stem Cells Source Type: research