Neurodegenerative disease: Actin up

Nature Reviews Neuroscience 17, 739 (2016). doi:10.1038/nrn.2016.151 Author: Sian Lewis The GGGGCC (G4C2) repeat expansion in the C9orf72 gene is a common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the mechanism is unknown. Using quantitative proteomics, the authors found that C9orf72 protein interacts with the actin-binding protein cofilin. Cofilin

http://feeds.nature.com/~r/nrn/rss/current/~3/4mAYmIGnXOQ/nrn.2016.151

Source: Nature Reviews Neuroscience - November 3, 2016 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research