Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis

Conclusions
Our results demonstrated that astrocytic activation but not microglial activation contributed to the allodynia in cyclophosphamide-induced cystitis and IL-1β released from astrocytes might bind to its endogenous receptor on the neurons inducing the phosphorylation of NR1 subunit, leading to sensory neuronal hyperexcitability and pathological pain.

Source: Molecular Pain - November 14, 2016 Category: Molecular Biology Authors: Liu, B., Su, M., Tang, S., Zhou, X., Zhan, H., Yang, F., Li, W., Li, T., Xie, J. Tags: Research Article Source Type: research