Intraosseous Injection of Simvastatin in Poloxamer 407 Hydrogel Improves Pedicle-Screw Fixation in Ovariectomized Minipigs

Conclusions:
A single intraosseous injection of simvastatin in thermosensitive poloxamer 407 hydrogel stimulated bone formation, increased BMD, improved bone microstructure, promoted osseointegration, and significantly enhanced the stability of pedicle screws in calcium-restricted ovariectomized minipigs.

Clinical Relevance:
These results provide rationale for evaluating intraosseous injection of simvastatin in poloxamer 407 to enhance implant fixation in patients with osteoporosis.

Source: JBJS - November 15, 2016 Category: Orthopaedics Authors: Fu, X., Tan, J., Sun, C. G., Leng, H. J., Xu, Y. S., Song, C. L. Tags: Basic Science Scientific Articles Source Type: research