Circulating Concentrations of Orexin A Predict Left  Ventricular Myocardial Remodeling

Among pivotal processes in heart failure (HF) progression is remodeling of the myocardium, which involves progressive cardiomyocyte cell death with interstitial fibrosis. On a macroscopic level, myocardial remodeling manifests as progressive increase in left ventricular (LV) volumes and reduction in ejection fraction (LVEF). LV reverse remodeling (LVRR) (i.e., reduction in LV volumes and improvement in LVEF) has been seen to follow initiation and up-titration of guideline-directed medical HF therapy (GDMT) and is associated with favorable outcome(1).
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research