Serial Changes in Cognitive Function Following Transcatheter Aortic Valve Replacement

BackgroundData regarding the mid- to long-term cognitive trajectory of transcatheter aortic valve (TAVR) recipients are scarce.ObjectivesChanges in global cognition and specific cognitive domains up to 1 year post-TAVR were evaluated.MethodsFifty-one patients (median age 80.0 [interquartile range: 72.0 to 85.0] years; 37% women) underwent TAVR and prospective assessment of cognitive function using the Montreal Cognitive Assessment (MoCA) at baseline, short-term (30 days), and 1 year post-TAVR. Processing speed and executive cognitive functions were further evaluated with the digit-symbol substitution test (DSST), Trail Making Tests (TMT), and verbal fluency tests at the same time points. Cognitive decline (CD) was determined by changes in mean scores and as a rate using practice-corrected reliable change index (RCI).ResultsThe baseline mean total MoCA score was 22.71 ± 3.84. Twenty patients (39.2%) were considered cognitively impaired using a cutoff of 
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research