Anti-CGRP antibodies block CGRP-induced diarrhea in mice

The multifunctional neuropeptide calcitonin gene-related peptide (CGRP) and its receptor are expressed throughout the gastrointestinal tract. Previous studies have shown that CGRP has roles in intestinal motility, water secretion, and inflammation. Furthermore, animal studies have demonstrated CGRP involvement in diarrhea secondary to C. difficile and food allergies. Diarrhea thus provides a convenient bioassay of CGRP activity in the GI system. In this proof of principle study, we report that prophylactic administration of an anti-CGRP antibody is able to block CGRP-induced diarrhea in mice.

Source: Neuropeptides - November 13, 2016 Category: Neuroscience Authors: Eric A. Kaiser, Brandon J. Rea, Adisa Kuburas, Brian R. Kovacevich, Leon F. Garcia-Martinez, Ana Recober, Andrew F. Russo Source Type: research