Activity of drugs against dormant Mycobacterium tuberculosis

Conclusion Lipophilic drugs were more active than hydrophilic agents against dormant Mtb in hypoxic conditions at pH 5.8. The Wayne model under slightly alkaline conditions was set up, and in hypoxic conditions at pH 7.3, rifampin and rifapentine were much more active than other drugs against NR Mtb. Overall, these models can be useful for testing drug activity against dormant Mtb under conditions mimicking the environments of cellular and caseous granulomas.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research