Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials
In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% confidence interval, 87%, >99%) in those receiving OST.
Source: Clinical Infectious Diseases - Category: Infectious Diseases Authors: Grebely, J., Dore, G. J., Zeuzem, S., Aspinall, R. J., Fox, R., Han, L., McNally, J., Osinusi, A., Brainard, D. M., Subramanian, G. M., Natha, M., Foster, G. R., Mangia, A., Sulkowski, M., Feld, J. J. Tags: BRIEF REPORTS Source Type: research