Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease

Conclusions. These findings indicate that circulating CRP and SAA levels are highest when the concentration of spirochetes is greatest in skin and/or blood and that levels decline after the dissemination of the organism to extracutaneous sites in subsequent stages of infection. The data also suggest that antibiotic-refractory Lyme arthritis and post-treatment Lyme disease syndrome are associated with elevated CRP responses that are driven by inflammatory mechanisms distinct from those in active infection.

Source: Clinical Infectious Diseases - November 11, 2016 Category: Infectious Diseases Authors: Uhde, M., Ajamian, M., Li, X., Wormser, G. P., Marques, A., Alaedini, A. Tags: ARTICLES AND COMMENTARIES Source Type: research