Fatal acute intoxication of accidentally ingested nifedipine in an infant – A case report

Dihydropyridine demonstrates greater selectivity for the calcium channels of vascular cells than for those of cardiac cells. Inhibiting calcium entry or release by blocking calcium channel suppresses the increase of the cytoplasmic calcium ion concentration, and causes relaxation of vascular smooth muscles and vasodilation [1]. Nifedipine is one dihydropyridine calcium channel blocking agent that is widely used as a first treatment of hypertension and angina pectoris [2 –4] because it rapidly and effectively decreases blood pressure compared with other drugs [5].
Source: Legal Medicine - Category: Forensic Medicine Authors: Tags: Case Report Source Type: research