Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall

Conclusions:
In the aortic wall, both HCTZ and spiro in antihypertensive doses reduce ROCK activation, subsequent expression of genes that promote vascular remodeling and hypertrophy in this experimental model of hypertension. These effects could explain some of their clinical benefits in hypertensive patients.

Source: Therapeutic Advances in Cardiovascular Disease - November 9, 2016 Category: Cardiology Authors: Araos, P., Mondaca, D., Jalil, J. E., Yanez, C., Novoa, U., Mora, I., Ocaranza, M. P. Tags: Original Research Source Type: research