Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics

Conclusions:
This work presents novel findings on the role of exercise training on cardiac remodeling induced by tobacco smoking. Although exercise has mitigated tissue fibrosis, their association with tobacco smoking exacerbated hypertrophy and in vitro myocardial dysfunction.

Implications:
This is first study to show that the association of an aerobic exercise training with tobacco smoking intensifies the phenotype of pathological cardiac hypertrophy. Therefore, the combination of interventions resulted in exacerbated myocardial hypertrophy and contractility dysfunction. These findings have significant clinical implication because some smoking people can be enrolled in an exercise-training program.

Source: Nicotine and Tobacco Research - November 9, 2016 Category: Addiction Authors: Reis Junior, D., Antonio, E. L., de Franco, M. F., de Oliveira, H. A., Tucci, P. J. F., Serra, A. J. Tags: Original Investigation Source Type: research