Tmod-34. reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

CONCLUSIONS:This study demonstrates that peri-tumoral astrocytes undergo temporal and spatial changes after surgical tumor resection, and that surgery-induced changes influence the aggressiveness of residual tumor. Gaining a better understanding of the post-surgical microenvironment will allow optimization of therapeutic strategies and facilitate the development of new approaches that ameliorate surgery-mediated effects on recurrent tumors.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Okolie, O., Bago, J., Schmid, R., Irvin, D., Bash, R., Miller, C. R., Hingtgen, S. Tags: TUMOR MODELS Source Type: research