Tmod-32. mathematically modeling perineural spread along peripheral nerves

The perineural spread of cancers to and along the peripheral nerve system is an emerging explanation for neoplastic plexopathy and underestimated source of patient morbidity and mortality. The perineural spread is a slowly growing process and can be difficult to detect without diligence for those at risk. This can lead to significant loss of mobility, function, and reduced quality of life for patients affected. Building on previous results in modeling glioblastoma multiforme, we present a mathematical model for predicting the course and extent of the perineural spread of recurrent tumors. By tracking cancer growth in the lumbosacral plexus on contrast enhancing images of two patients (one with prostate cancer, one with cervical cancer) we calibrate a model for growth in a digitized atlas. We successfully modeled and simulated perineural growth in both patients. Although in early stages of development, our model shows promise in predicting the course and extent of perineural spread for many types of recurrent cancers. Furthermore, it may be used to evaluate the effectiveness of treatment in deflecting the growth of disease and maintaining function. Coupled with molecular profiles from multiple primary cancers, mathematical modeling may be a powerful tool in preventing or treating their perineural spread.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: TUMOR MODELS Source Type: research