Tmod-22. snail1 regulates gliomagenesis independent of its mesenchymal function

CONCLUSION:Our data confirms a dual role for SNAIL1 in glioma progression, in which it cooperates with oncogenes to promote early transformation while independently also regulating mesechnymal changes at later stages of tumor development. Our platform combining RNAseq expression profiling and computational network analysis with biological validation provides a potentially powerful tool to study mechanistic events as low-grade gliomas become transformed into malignant gliomas.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Nguyen-Tran, D.-H., Kabbout, M., Le, S., Tran, D. Tags: TUMOR MODELS Source Type: research