Tmod-07. cellular origins of glioblastoma: lessons from mouse models

A central question in glioblastoma research is the identity of the tumor-initiating cell and its contribution to the malignant phenotype and genomic state. We systematically examined the potential of adult CNS progenitors, and immature and mature neurons to induce fully penetrant glioblastoma using lineage-specific inducible cre mice to inactivate the tumor suppressors Nf1, Trp53 and Pten. Adult CNS progenitors give rise to phenotypically and molecularly distinct tumor subtypes, which, despite histologic identity as glioblastoma, are separable based on the lineage of the cell of origin. Mutations induced in adult neurons do not lead to tumor development. These studies identify adult lineage-restricted CNS progenitors but not neurons as tumor-initiating cells and point to the cell of origin as a major determinant of glioblastoma subtype diversity.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Llaguno, S. A., Wang, Z., Sun, D., Chen, J., Pedraza, A., Xu, J., Kim, E., Hatanpaa, K., Raisanen, J., Burns, D., Johnson, J., Parada, L. Tags: TUMOR MODELS Source Type: research