Surg-37. modern postoperative seizure prophylaxis with levetiracetam in over 300 newly diagnosed glioblastoma patients

CONCLUSION:Our large retrospective study of modern seizure prophylaxis with levetiracetam revealed the initial post-operative week to be the most common seizure period regardless of pre-operative seizure status, emphasizing the timeframe during which patients without seizures should be prophylaxed and suggesting consideration for a second agent during this period in patients with preoperative seizures. Furthermore, the neurosurgeon’s discretion to choose which patients without preoperative seizures to give prophylactic levetiracetam to may select high risk patients, the variables of which we will seek to define, shedding light on the difficulty of randomized trials studying levetiracetam prophylaxis.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Jahangiri, A., Flanigan, P. M., Choi, S., Chou, A., Arnush, M., Bruhn, J., Kuang, R., Truong, A., Clarke, J., Chang, E., McDermott, M., Chang, S., Berger, M. S., Aghi, M. Tags: SURGICAL THERAPY Source Type: research