Stmc-36. cd109 regulates tumor propagation of radio-resistant glioma stem cells
In this study we discovered CD109 as a novel tumor initiation marker for the MES subtype of glioma stem cells. Here we report that exposure of glioma stem-like cells (GSCs) to ionizing radiation (IR) promotes a persistent transcriptomic and phenotypic shift toward a MES subtype in a CD109-dependent manner. We observed that in both de novo and IR-induced MES GSCs, CD109+, but not CD109- populations are highly clonogenic in vitro and radio-resistant and tumorigenic in vivo. In addition, inhibition of CD109 through shRNAs attenuates clonogenicity, tumor propagation and radio-resistance and dramatically inhibits YAP/TAZ signaling in MES GSCs. In support of these results, CD109 is significantly associated with the MES subtype of GBMs, correlates with YAP/TAZ expression, and poorer prognosis of GBM patients.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Audia, A., Minata, M., Guo, X., Mukheef, F., Patel, H., Ezhilarasan, R., Sulman, E., Nakano, I., Bhat, K. Tags: STEM CELLS Source Type: research
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