Stmc-17. n-cadherin upregulation mediates slow proliferation and therapeutic resistance in glioma stem cells

In conclusion, our data indicate that increased N-cadherin expression induces a state of slow growth in GSCs through a reduction of Wnt/ β-catenin signaling, which underlies their therapeutic resistance. Therefore, N-cadherin represents a new important target to antagonize tumor recurrence in glioblastoma.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Osuka, S., Sampetrean, O., Onishi, N., Saya, H., Meir, E. V. Tags: STEM CELLS Source Type: research