Rthp-22. inflammatory response after modified nanotherm and radiotherapy of recurrent glioblastoma

CONCLUSION:This is the first report demonstrating that the combination of modified NanoTherm therapy with radiotherapy can induce a strong inflammatory reaction at the resection cavity mimicking abscess formation. We assume that large amounts of cellular debris are released in situ, which can serve as a source of tumor antigens to elicit host CD8+T-cell mediated adaptive immune responses against the tumor. Further investigations are necessary to decipher immune-related effects of modified NanoTherm therapy.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Grauer, O., Jaber, M., Hess, K., Weckesser, M., Schwindt, W., Maring, S., Stummer, W., Wölfer, J. Tags: RADIATION THERAPY Source Type: research