Rare-63. multicentric glioma in ollier disease: a case report and review of the literature

CONCLUSIONS:This case reinforces the association between OD and gliomagenesis. Additionally, multicentric glioma in OD is exceptional. The mutant isocitrate dehydrogenase (IDH) 1 pathway in this patient’s gliomas may represent the driving oncogenic pathway for his condition. Increasing evidence supports the concept of somatic heterozygous mutations of IDH1 and IDH2 playing a central role in tumorigenesis in OD, with this aberrant pathway contributing to the development of both mesenchymal and glial tumors. Further characterization of gliomas in OD is essential to our understanding of their pathogenesis, and may illuminate potential therapeutic avenues for glioma arising in the setting of OD.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RARE TUMORS Source Type: research