Rare-42. leptomeningeal dissemination in malignant glioma: a case series

We report a case series of 11 patients over 18 months at a single institution. Demographic, radiologic, and treatment data from the medical record are reported, and molecular characteristics of the primary tumor identified where available. Demographic and clinical features were strikingly variable. Time from initial diagnosis to LM diagnosis varied from synchronous to 30 years. Time to LM development from initial diagnosis was significantly longer for those whose tumors were initially low grade. There was no predilection for tumor location and all but the two patients (both diagnosed synchronously) received radiation and chemotherapy following initial surgery. Patients who received treatment for LM lived longer than those who did not, but the small sample size and additional variables (e.g. KPS and IDH mutation status) precluded a statistical assessment. There was a positive correlation between KPS at LM diagnosis and survival (r = 0.726027). However, relationships between the data were highly variable across the group, likely confounding results. For example, two of 4 patients who chose no treatment (one with a KPS of 90%) had IDH1 mutations but poor survival, suggesting a complex relationship between this prognostic variable and survival in LM. We are using cancer genomics in an attempt to identify molecular signatures associated with LM. Whole exome sequencing and gene expression profiling from available tissue samples is ongoing and results will be rep...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RARE TUMORS Source Type: research