Rare-33. intracerebral hemorrhage as rare complication of intravascular lymphoma

Intravascular lymphoma (IVL) is an aggressive multifocal large cell lymphoma, characterized by neoplastic proliferation and vascular occlusion within the lumina of arterioles, capillaries and venules with a predilection for the central nervous system and skin. The clinical presentation is frequently non-specific and may consist of changes in mental status, focal neurological deficits, seizures, fevers of unknown origin and skin changes. Due to the rarity and absence of specific diagnostic procedures apart from biopsy, diagnosis is difficult and often post-mortem. Neuroimaging findings vary widely, ranging from normal to diffuse white matter involvement, multifocal mass lesions or restricted diffusion with or without enhancement. Prior literature has reported only two cases of IVL presenting with hemorrhagic foci in absence of disseminated intravascular coagulation (DIC). The purpose of this poster is to review a rare presentation of IVL involving intracerebral hemorrhage through a 58 year-old male who presented with acute onset global aphasia and right sided weakness. The patient initially received IV tissue plasminogen activator (TPA) given concern for stroke. The patient’s clinical course was complicated by fluctuating neurological symptoms and intermittent seizures over a two month period with subsequent neuroimaging demonstrating multiple progressive subcortical hemorrhages. The diagnosis of IVL remains a challenge and increasing awareness to hemorrhagic findin...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RARE TUMORS Source Type: research