Rare-16. a case report of autograft olfactory stem cell transplant for spinal cord injury developing into a persistent spinal mass

We report a case of olfactory mucosal stem cell transplantation for traumatic SCI at the level of C6-7. Three years after the transplant, the patient developed new neurological symptoms of arm weakness. MRI showed a multi-lobulated mass at the site of the stem cell transplant. The tumor was surgically removed and pathological analysis revealed mucosal cells within the mass suggesting that it had originated from the olfactory mucosal transplant. The patient had to undergo several resections due to regrowth of the mass and recurrent symptoms. To our knowledge this is only the third reported case of mass formation following stem cell transplant into central nervous system tissue. This case represents a disastrous complication of stem cell transplantation and highlights the need for additional clinical studies to validate the use of stem cell transplant for the treatment.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RARE TUMORS Source Type: research