Rare-15. postoperative managements for adult pilocytic astrocytomas: efficacy of upfront radiation therapy and radiosurgery

This study was designed to evaluate the surgical outcome of adult PAs and to assess the efficacy of the upfront radiation therapy (RTx) and radiosurgery for residual tumors. A total of 63 consecutive adult patients with newly diagnosed PAs were retrospectively reviewed. Thirty-Two patients (50.8%) were male, and the median patient age was 28 years (range, 18 – 79 years). There were 21 supratentorial hemisphere tumors (33.3%), 11 supratentorial axial tumors (17.5%), and 31 infratentorial tumors (49.2%). Fifty-four patients (85.7%) underwent surgical resection and 9 patients (14.3%) did only biopsy. Forty-one patients (65.1%) underwent gross total removal (GTR), 13 patients (20.6%) subtotal removal (STR), and 9 patients (14.3%) only biopsy. The recurrence rates were 9.8% (4/41), 23.1% (3/13), and 55.6% (5/9) in the GTR, STR, and biopsy group, respectively, and the overall recurrence rate was 19.0% (12/63). Of the 22 patients who did not underwent GTR, 7 patients received RTx, 4 patients reoperation, 3 patients radiosurgery, and 8 patients observation. The final recurrence rates were 57.1% (4/7), 33.3% (1/3), and 25% (2/8) in the RTx, radiosurgery, and observation groups, respectively. The adult PAs showed more aggressive clinical course. The efficacy of the upfront RTx or radiosurgery was questionable.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RARE TUMORS Source Type: research