Qlif-21. quality of life domains in relation to glioma grade

Cancer-related quality of life (QOL) factors, some of which are unique to brain tumor patients with glioma, have not been well-studied by glioma grade. To examine potential differences in QOL factors among patients with primary glioma, the validated self-administered instrument, FactBr (Functional Assessment of Cancer Therapy for patients with Brain cancer) version 3, was used to collect QOL data from 754 participants with histologically confirmed WHO (World Health Organization) grade II (n=150), grade III (n=149) or grade IV (n=455) glioma in the San Francisco Bay Area Adult Glioma Study. Time since diagnosis and treatments received varied because patients were recruited as they came to the UCSF Neuro-oncology clinic. QOL domains were computed for physical [7 questions], social [7 questions], emotional [6 questions], functional [7 questions]) and brain/neurocognitive (19 questions) well-being. Analysis of variance methods adjusted for age-group at diagnosis and days from diagnosis to interview (quartiles) were employed to examine differences in well-being scores by grade. Physical, social, emotional and functional well-being, and composite scores for total well-being and general well-being (brain score excluded) did not differ by grade. Brain well-being differed by grade (p=0.02) with post-hoc multiple comparisons of marginal means showing that compared with grade IV patients, brain well-being scores were higher for patients with grade II but not with grade III glioma (Tukey...

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Bracci, P., Chang, S., Clarke, J., Claus, E., Lachance, D., Luks, T., McCoy, L., Molinaro, A., Taylor, J., Wiemels, J., Wiencke, J., Wrensch, M. Tags: QUALITY OF LIFE Source Type: research