Intestinal multidrug resistance-associated protein 2 is down-regulated in fructose-fed rats

Expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2) and glutathione-S-transferase (GST) were examined in fructose fed Wistar rats, an experimental model of metabolic syndrome. Animals were fed on (i) control diet or (ii) control diet plus 10% w/vol fructose in the drinking water. Mrp2 and the α class of GST proteins as well as their corresponding mRNAs were decreased, suggesting a transcriptional regulation by fructose. Confocal microscopy studies reaffirmed down-regulation of Mrp2.

Source: The Journal of Nutritional Biochemistry - November 8, 2016 Category: Biochemistry Authors: AS Londero, MR Arana, VG Perdomo, GN Tocchetti, F Zecchinati, CI Ghanem, ML Ruiz, JP Rigalli, AD Mottino, F Garc ía, SSM Villanueva Source Type: research