Cancer du sein et diab ète de type 2 : des interactions complexes

Conclusion Les médecins confrontés à une patiente diabétique traitée pour un cancer du sein ont un rôle pour choisir le meilleur anti-diabétique et mettre en œuvre des mesures hygiéno-diététiques. Les femmes diabétiques sans cancer du sein devraient participer aux programmes organisés de dépistage et bénéficier d’un examen clinique mammaire annuel. The aim of this literature review was to quantify the incidence and mortality of breast cancer for women treated for a diabetes mellitus and to analyze the complex relationship between these two common diseases. Methods The articles analyzed were extracted from the PubMed database from 2000 to 2015. A total of 22 case/control studies or cohorts were retained, allowing the realization of a meta-analysis. Results The incidence of breast cancer for women with diabetes is significantly increased for cohorts (RR=1.32; 95% CI: 1.06 to 1.65) and not significantly for case/control studies (RR=1.46; 95% CI: 0.99 to 2.26). Overall, mortality of women with breast cancer is significantly increased for diabetic patients compared with non-diabetic patients (RR=1.53; 95% CI: 1.23 to 1.90). The links between diabetes and breast cancer are explained by common risk factors (overweight/obesity, qualitative and quantitative dietary errors, physical inactivity), biological changes and the impact of some anti-diabetic treatments or hormonotherapy. Conclusion Physicians facing a diabetic patient treated for breast cancer have a role...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research