Combination of the anthocyanidins malvidin and peonidin attenuates LPS-mediated inflammatory gene expression in primary human adipocytes

We recently demonstrated that California table grapes and a methanol-extractable, polyphenol-rich fraction decreased adiposity, insulin resistance, or markers of inflammation in high-fat fed mice. Malvidin and peonidin glycosides were the two most abundant anthocyanins in the polyphenol-rich fraction. We hypothesized that a blood borne combination of anthocyanidins malvidin and peonidin derived from intestinal β-glycosidase metabolism of these two anthocyanins are responsible, in part, for the beneficial health effects observed in vivo.

Source: Nutrition Research - November 8, 2016 Category: Nutrition Authors: Jessica D. Mackert, Michael K. McIntosh Source Type: research