Association between SLC11A1 (NRAMP1) polymorphisms and susceptibility to tuberculosis in Chinese Holstein cattle

We investigated the associations between SLC11A1 (NRAMP1) polymorphisms and susceptibility to tuberculosis (TB) in Chinese Holstein cattle from the Yunnan Plateau, China, using a case-control study. The case group included 136 animals that had positive reactions to both a purified protein derivative test and an IFN- γ assay, as well as showing clinical symptoms of TB, and the control group included 96 animals that had negative reactions to both testsand showed no symptoms. Polymerase chain reaction (PCR) sequencing and the PCR-restriction fragment length polymorphism (RFLP) technique were used to detect and de termineSLC11A1 (NRAMP1) polymorphisms.

Source: Tuberculosis - November 7, 2016 Category: Respiratory Medicine Authors: Kaihua Liu, Bin Zhang, Zhaochun Teng, Youtao Wang, Guodong Dong, Cong Xu, Bo Qin, Chunlian Song, Jun Chai, Yang Li, Xianwei Shi, Xianghua Shu, Yifang Zhang Source Type: research