Primed neutrophil infiltrations into multiple organs in child physical abuse cases: a preliminary study

Studies have suggested that ‘primed’ polymorphonuclear neutrophils may contribute to multiple organ injury in cases of extensive trauma and following traumatic or hemorrhagic shock. These cells produce inflammatory mediators, such as neutrophil elastase (NE), leukotrienes, cyclooxygenase (COX)-2, reactive oxygen species (R OS), and proinflammatory cytokines [1–11]. Multiple injuries of different ages are usually observed over the whole body in cases of physical abuse [12,13]. Recently, we reported that the physical abuse of the elderly induces massive primed neutrophil infiltration into the lungs and liver.

Source: Legal Medicine - November 7, 2016 Category: Forensic Medicine Authors: Takahito Hayashi, Takuma Nakamae, Eri Higo, Kazuya Ikematsu, Mamoru Ogata Source Type: research