Correlation of florbetaben PET imaging and the amyloid peptide A ß42 in cerebrospinal fluid

Today, the use of biomarkers such as amyloid-specific positron emission tomography (PET) tracers and information derived from cerebrospinal fluid (CSF) can support the diagnosis of Alzheimer ´s disease (AD) as an indicator for the presence of amyloid pathology. We here show that the PET signal of the 18F-labelled tracer florbetaben (NeuraCeqTM), that binds to amyloid-beta plaques, inversely correlates with CSF levels of Aß42, another biomarker for AD. Results from the two biomarkers w ere concordant in 34 out of 38 subjects.

Source: Psychiatry Research: Neuroimaging - November 4, 2016 Category: Psychiatry Authors: Carola G. Schipke, Norman Koglin, Santiago Bullich, Lisa Katharina Joachim, Brigitte Haas, John Seibyl, Henryk Barthel, Osama Sabri, Oliver Peters Source Type: research