Mixed metal oxide nanoparticles inhibit growth of Mycobacterium tuberculosis into THP-1 cells

Conclusion Although Ag NPs exhibited low cytotoxicity, they were unable to inhibit Mtb growth in vitro. ZnO NPs exhibited strong anti-Mtb activity and inhibited bacterial growth, but exhibited high cytotoxicity to human macrophage cells. By mixing Ag and ZnO NPs at a ratio of 8ZnO/2Ag, we acquired a mixture that exhibited potent antibacterial activity against Mtb and no cytotoxic effects on THP-1 cells, resulting in inhibition of both in vitro and ex vivo Mtb growth Figs. 1–3, Tables 1–3.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research