The neuropeptide galanin modulates natural killer cell function

Natural killer (NK) cells are part of the innate immune system and combat pathogens and tumors by secreting pro-inflammatory cytokines like interferon gamma (IFN- γ) and by their cytotoxic action. Galanin is a neuropeptide also expressed in peripheral tissue where it impacts several physiological functions, including inflammation. The effects of galanin are mediated via three receptors, GAL1–3. Since other neuropeptides have been shown to regulate NK cell activity, we investigated the potential of galanin to modulate human NK cell function.

Source: Neuropeptides - November 3, 2016 Category: Neuroscience Authors: Andreas Koller, Rodolfo Bianchini, Sandra Schlager, Christian M ünz, Barbara Kofler, Silke Wiesmayr Source Type: research