PET measurement of “GABA shift” in the rat brain: a preclinical application of bolus plus constant infusion paradigm of [18F]flumazenil

We measured the tiagabine-induced enhancement of the GABAA receptor's affinity for benzodiazepine ligands ( “GABA shift”) using [18F]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [18F]FMZ binding were compared to that of [18F]FMZ PET with single bolus injection (SB).
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research