Endonuclease mediated genome editing in drug discovery and development: promises and challenges

Publication date: Available online 2 November 2016 Source:Drug Discovery Today: Technologies Author(s): Vidya Prabhu, Han Xu Site specific genome editing has been gradually employed in drug discovery and development process over the past few decades. Recent development of CRISPR technology has significantly accelerated the incorporation of genome editing in the bench side to bedside process. In this review, we summarize examples of applications of genome editing in the drug discovery and development process. We also discuss current hurdles and solutions of genome editing.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research