Oxyntomodulin analog and exendin-4 derivative lower plasma glucose in cattle

The present study was undertaken with the aim of examining whether and how exendin-4 (1-3) fragment, i.e., Ex-4 (1-3) fragment, contributes to the regulation of glucose. An analog of oxyntomodulin (OXM) ([Gly2, Glu3]-OXM), a glucagon analog ([Gly2, Glu3]-glucagon) and two derivatives of Ex-4 (glucandin and [Gly2, Glu3]-glucandin) were synthesized by substituting with Gly2, Glu3 at the N terminuses of OXM and glucagon and/or by attaching Ex-4 (30-39) amide at the C terminus of glucagon. Effects of these peptides on plasma insulin and glucose concentrations were investigated in cattle by conducting three in vivo experiments.

Source: Domestic Animal Endocrinology - November 1, 2016 Category: Endocrinology Authors: S. ThanThan, Y. Asada, T. Saito, K. Ochiiwa, H. Zhao, S.W. Naing, H. Kuwayama Source Type: research