Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia

Conclusion
These data demonstrate elevated IGFBP-7 and TIMP-2 levels in ARAS as a function of the degree of reduced RBF. Elevated baseline IGFBP-7 levels were associated with protection against postimaging hypoxia, consistent with ‘ischemic preconditioning’. Despite contrast injection and stenting, AKI in these high-risk ARAS subjects with elevated IGFBP-7/TIMP-2 was rare and did not affect long-term kidney function.

Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Saad, A., Wang, W., Herrmann, S. M. S., Glockner, J. F., Mckusick, M. A., Misra, S., Bjarnason, H., Lerman, L. O., Textor, S. C. Tags: Acute Kidney Injury Source Type: research