Regulation of pulmonary endothelial barrier function by kinases

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Source: AJP: Lung Cellular and Molecular Physiology - October 31, 2016 Category: Respiratory Medicine Authors: Barabutis, N., Verin, A., Catravas, J. D. Tags: REVIEWS Source Type: research