Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions

This article reviews the current knowledge and unanswered questions in the pathobiology of the chemical and molecular factors in IBS. Evidence continues to point to significant roles in pathogenesis of these chemical and molecular mechanisms, which may therefore constitute potential targets for future research and therapy. However, it is still necessary to address the interaction between these factors in the gut and to appraise how they may influence hypervigilance in the central nervous system in patients with IBS.
Source: AJP: Gastrointestinal and Liver Physiology - Category: Gastroenterology Authors: Tags: REVIEWS Source Type: research