Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension

In conclusion, in ANG II-induced hypertension, genetic deletion of Gal-3 prevented LV dysfunction without affecting blood pressure or LV hypertrophy. This study indicates that the ANG II effects are, in part, mediated or triggered by Gal-3 together with the related intercellular signaling (ICAM-1 and IL-6), leading to cardiac inflammation and fibrosis.

Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Gonzalez, G. E., Rhaleb, N.- E., D'Ambrosio, M. A., Nakagawa, P., Liao, T.-D., Peterson, E. L., Leung, P., Dai, X., Janic, B., Liu, Y.-H., Yang, X.-P., Carretero, O. A. Tags: Integrative Cardiovascular Physiology and Pathophysiology Source Type: research