GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries

In conclusion, GLP-1 reduced relaxation induced by VEGFA in resistance arteries by inhibiting VEGFR2-mediated Ca2+ signaling and endothelial NO synthesis. GLP-1, on its own, also induced phosphorylation of Src and ERK1/2 that can lead to proliferation and is implicated in vessel permeability.

Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Egholm, C., Khammy, M. M., Dalsgaard, T., Mazur, A., Tritsaris, K., Hansen, A. J., Aalkjaer, C., Dissing, S. Tags: Vascular Biology and Microcirculation Source Type: research