DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia

We found microstructural differences between adolescent COS siblings and age-matched control participants with greater mean diffusivity (MD) in the putamen in controls compared to COS siblingsOur data also reveal widespread increased white matter MD, radial diffusivity (RD), and axial diffusivity (AD) throughout the brain in the COS siblings compared to controls.Increases in white matter fractional anisotropy (FA) and decreases in MD, RD, and AD were associated with worse task performance in COS siblings.

Source: Psychiatry Research: Neuroimaging - October 31, 2016 Category: Psychiatry Authors: Dana Waltzman, Barbara Jean Knowlton, Jessica Rachel Cohen, Susan Yost Bookheimer, Robert Martin Bilder, Robert Franklin Asarnow Source Type: research