Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells

This study establishes the complexity of CDCA signaling in the colonic epithelium and shows the contribution of EGFR, EPAC, and Ca2+ in CDCA-induced activation of CFTR-dependent Cl– secretion.

Source: AJP: Cell Physiology - October 31, 2016 Category: Cytology Authors: Domingue, J. C., Ao, M., Sarathy, J., Rao, M. C. Tags: ARTICLES Source Type: research