Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice

ConclusionPreaxial polydactyly can be caused in the developing embryo by acute maternal administration of a Smo agonist that activates HH signaling. These results are consistent with the preaxial polydactyly induced in developmental disorders associated with mutations in HH signaling genes.Birth Defects Research (Part A), 2016.© 2016 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 30, 2016 Category: Perinatology & Neonatology Authors: Eric W. Fish, Scott E. Parnell, Kathleen K. Sulik, Lorinda K. Baker, Laura B. Murdaugh, David Lamson, Kevin P. Williams Tags: Brief Report Source Type: research