Glycated Hemoglobin, Plasma Glucose, and Erythrocyte Aging

Conclusions:
RBC turnover seems to be dominated by a constant rate of cell loss, and a mechanism that targets cells of a specific age. Average RBC life span is 80 ± 10.9 days. Of HbA1c change toward treatment goal value, 50% is reached in about 30 days. Many factors contribute to the ratio of glycated hemoglobin, yet we can make accurate estimations considering only the in vivo glycation constant, MBG, and the age distribution of erythrocytes.

Source: Journal of Diabetes Science and Technology - October 31, 2016 Category: Endocrinology Authors: Beltran del Rio, M., Tiwari, M., Amodu, L. I., Cagliani, J., Rodriguez Rilo, H. L. Tags: Original Articles Source Type: research